One hundred and sixteen patients with advanced squamous cell carcinoma of the oral cavity and oropharynx were treated with irradiation and surgery. Failures were correlated with respect to tumor factors and treatment. Associated with failures are: (a) cut-through of disease at the primary site, (b) connective tissue involvement in the neck, (c) insufficient dose or use of a wedge pair, and (d) failure to give elective treatment to the neck. There is no significant difference in control in the pre- vs. the postoperative group. Combined treatment is indicated in those patients with a high risk of failure if treated by either modality alone.
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Hamberger et al. (1976) studied this question.
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