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Requires caution extrapolating angiotensin I effects clinically; leaves open standardization amid literature inconsistencies.
It is generally accepted that the biological activity of 5-isoleucine- and 5-valine-angio-tensin II is equal even when aspartic acid in position 1 is substituted by asparagine (1). Angiotensin I has approx. one third the pressor activity of angiotensin II (1). However, a survey of literature reveals certain inconsistencies (2–10) (Table 1).
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Nakajima et al. (1973) studied this question.
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