Blood samples from out-patients of Donner Laboratory and Alta Bates Hospital were studied through measurements of the nuclear magnetic resonance (NMR) relaxation times (T1‘s). Non-leukemic whole blood showed a very nearly linear relationship between 1/T1 values and the hemoglobin concentrations. Blood samples from leukemic patients exhibited a marked departure from the non-leukemic T1 values with corresponding hemoglobin concentrations. Further measurements on blood plasma, packed red cells and whole blood are described. Discussions of the causes of the NMR proton relaxation time variations are given with reference to the basic theories of oxygenation of blood. Proton relaxation times are also affected strongly by protein concentration levels.
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Singer et al. (1978) studied this question.
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