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February 1, 2004The Journal of ImmunologyOpen Access

TNF-α-Induced Apoptosis of Macrophages Following Inhibition of NF-κB: A Central Role for Disruption of Mitochondria

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Authors

HLHongtao LiuNorthwestern UniversityYMYingyu MaNorthwestern UniversityLPLisa J. PagliariLa Jolla Institute for Immunology

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Liu et al. (2004) studied this question.

synapsesocial.com/papers/6a893abcf8670bac6e3334abhttps://doi.org/10.4049/jimmunol.172.3.1907
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macrophages Require Constitutive NF-κB Activation To Maintain A1 Expression and Mitochondrial Homeostasis2000 · 151 citations
  2. 2NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis1999 · 590 citations
  3. 3Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death1999 · 1,070 citations
  4. 4A20 Inhibits Tumor Necrosis Factor (TNF) Alpha-Induced Apoptosis by Disrupting Recruitment of TRADD and RIP to the TNF Receptor 1 Complex in Jurkat T Cells2002 · 197 citations