1,4-Palladium Shift/C(sp3)–H Activation Strategy for the Remote Construction of Five-Membered Rings

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1, n -Metal shift is an elegant alternative approach enabling the functionalization of remote C–H bonds from simple precursors. In this work, we report a novel and simple Pd 0 -catalyzed domino reaction involving 1,4-palladium shift and C(sp 3 )–H activation and leading to (fused) five-membered rings. This method allowed access to a broad range of valuable arylidene γ-lactams and indanones and was applied to the formal synthesis of (−)-pyrrolam.