Lipid-plasmid DNA(pDNA)-gold nanoparticle(AuNP) hybrids are synthesized and used for gene delivery (see image). The loading of DNA strands onto AuNPs allows for their support and stabilization by the NPs; many DNA strands are delivered per delivery event. These results show that lipids and AuNP in one hybrid can work synergistically for improved gene delivery.
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Rhim et al. (2008) studied this question.
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