Why the study?
Does aspirin alter acetylcholine-evoked endothelium-dependent cutaneous vasodilatation in women with primary Raynaud's disease compared to controls?
Does aspirin alter acetylcholine-evoked endothelium-dependent cutaneous vasodilatation in women with primary Raynaud's disease compared to controls?
Primary Raynaud's disease is associated with an abnormality in the ability of estrogen to modulate the synthesis of endothelium-dependent vasodilator and/or vasoconstrictor COX products.
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Aspirin effects on cutaneous vasodilation differ by Raynaud's status and menopause; hypothesis-generating for estrogen-COX interactions, does not yet inform practice.
Easter et al. (2005) studied this question.
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