What question did this study set out to answer?

Examine the distinct roles of neurotrophin receptors p75NTR and TrkC in regulating peripheral nervous system myelination.

November 8, 2002Science

The Neurotrophin Receptor p75 NTR as a Positive Modulator of Myelination

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Authors

JCJosé Miguel CosgayaInstituto de Investigaciones Biomédicas Sols-Morreale JCJonah R. ChanUniversity of California, San Francisco ESEric M. ShooterUniversity of Southern California

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Implication

Laboratory investigation demonstrates opposite roles for p75NTR and TrkC in peripheral nerve myelination, highlighting distinct pathways for nerve repair.

Key Points

Examine the distinct roles of neurotrophin receptors p75NTR and TrkC in regulating peripheral nervous system myelination.
Assessed myelin sheath formation in peripheral nerve models with and without functional p75NTR.
Evaluated myelination changes following the blockade of TrkC receptor activity.
Analyzed the receptor-specific contributions of endogenous brain-derived neurotrophic factor and neurotrophin-3.
Myelin formation was inhibited in the absence of functional p75NTR and significantly enhanced when TrkC activity was blocked.
Endogenous brain-derived neurotrophic factor promoted myelination through p75NTR, whereas neurotrophin-3 inhibited myelination via TrkC receptors.

Cite This Study

Cosgaya et al. (2002) studied this question.

synapsesocial.com/papers/6a893f0f83a8265f5d333290 https://doi.org/10.1126/science.1076595

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Implication

Laboratory investigation demonstrates opposite roles for p75NTR and TrkC in peripheral nerve myelination, highlighting distinct pathways for nerve repair.

The Neurotrophin Receptor p75 NTR as a Positive Modulator of Myelination

Discussion

Member takes

Implication

Key Points

Cite This Study

The Neurotrophin Receptor p75 NTR as a Positive Modulator of Myelination

Discussion

Member takes

Implication

Key Points

Cite This Study

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