Why the study?
Does the endothelin A receptor selective antagonist BMS-193884 cause vasodilation and attenuate ET-1 induced vasoconstriction in healthy men?
Does the endothelin A receptor selective antagonist BMS-193884 cause vasodilation and attenuate ET-1 induced vasoconstriction in healthy men?
BMS-193884 demonstrates ETA receptor selectivity, producing both local and systemic vasodilation while effectively attenuating ET-1-induced vasoconstriction in healthy men.
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Supports oral ETA antagonism for vasodilation in humans; extends preclinical data to justify patient trials.
Dhaun et al. (2005) studied this question.
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