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Coxsackieviruses are ubiquitous and highly infectious in normal children, with peak isolation in warmer months, emphasizing the utility of complement-fixation tests and suckling mice for diagnosis.
Two hundred and thirty-nine group A coxsackieviruses and 25 group B coxsackieviruses were isolated from 1,597 specimens from 625 normal children in a crèche over a 22-month period. The highest isolation rate was achieved in the warmer months, reaching a peak isolation rate of 70% in December, 1966. The viruses are ubiquitous and very infectious. One individual may be excreting one or more different types for a number of weeks. The complement-fixation test is a reliable, quick means of identifying group A coxsackieviruses. The incidence of coxsackievirus infections in clinical cases during the same period is discussed. The study emphasizes the need to use suckling mice in diagnostic virology.
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Cook et al. (1969) studied this question.
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