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January 14, 2014Hypertension

Inhibition of sAC by KH7 and anti-sAC siRNA significantly reduced cAMP response element-mediated promoter activity, decreased expression of ENaC-α and Na+/K+-ATPase-α, and resulted in significant endothelial cell softening.

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Population

Vascular endothelial cells and kidney collecting duct cells

Design

Preclinical

Authors

BSBoris SchmitzJNJohanna NedeleKGKatrin Guske

Discussion

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Overview

Hypothesis-generating for sAC inhibition in endothelial protection; leaves open translation to human hypertension.

Structured PICO

P
Population
Vascular endothelial cells and kidney collecting duct cells
I
Intervention
Inhibition of soluble adenylyl cyclase (sAC) using specific inhibitor KH7 and anti-sAC small interfering RNA
O
Outcome
Endothelial stiffness and cAMP response element-mediated transcriptional activationsurrogate

Soluble adenylyl cyclase regulates gene expression involved in aldosterone signaling and modulates endothelial stiffness, highlighting a potential therapeutic target for vascular protection.

Cite This Study

Schmitz et al. (2014) studied this question.

synapsesocial.com/papers/6a89427f7fec28afabc11000https://doi.org/10.1161/hypertensionaha.113.02061
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Also Consider

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