Within a few minutes after application to the surface of human skin, hydrocortisone and fluocinolone acetonide in the presence of dimethylsulfoxide (DMSO) are established in a protected reservoir in the stratum corneum. This reservoir remains over a 16 day period and is resistant to washing of the skin surface with soap, water, and alcohol.
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Richard B. Stoughton (1965) studied this question.
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