August 1, 1987Biochemical JournalOpen Access

Effects of Mg2+, anions and cations on the Ca2+ + Mg2+-activated ATPase of sarcoplasmic reticulum

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Population

Sarcoplasmic reticulum Ca2+ + Mg2+-activated ATPase

Design

Preclinical

Authors

HSH.I. StefanovaUniversity of Southampton RNRichard NapierUniversity of Warwick JEJ. Malcolm EastUniversity College of the North

Discussion

Member takes

Implication

May inform SERCA kinetics in cardiac models; leaves open relevance to in vivo contractility or HF therapies.

Structured PICO

Population

Sarcoplasmic reticulum Ca2+ + Mg2+-activated ATPase

Intervention

Mg2+, cations (K+, Na+, NH4+, Li+, choline+), and anions (I-, SCN-, Cl-)

Outcome

ATPase activity and kinetic parameterssurrogate

The study extends a kinetic model of sarcoplasmic reticulum ATPase to explain how Mg2+, cations, and anions modulate its activity through competitive binding and conformational transition rate changes.

Cite This Study

Stefanova et al. (1987) studied this question.

synapsesocial.com/papers/6a894488b1e5d05ea8ec668d https://doi.org/10.1042/bj2450723

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Effects of Mg2+, anions and cations on the Ca2+ + Mg2+-activated ATPase of sarcoplasmic reticulum

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Mg2+, anions and cations on the Ca2+ + Mg2+-activated ATPase of sarcoplasmic reticulum

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider