Why the study?
Vascular endothelium involvement is recognized in COVID-19 complications, prompting focus on therapeutical strategies targeting the vascular endothelium to reduce these risks.
Do therapeutical strategies targeting the vascular endothelium reduce the risk of complications in patients with coronavirus disease 2019?
Do therapeutical strategies targeting the vascular endothelium reduce the risk of complications in patients with coronavirus disease 2019?
Targeting the vascular endothelium may be a viable therapeutic strategy to reduce severe complications such as endotoxic shock and cardiovascular collapse in COVID-19.
Hypothesis-generating for endothelial targeting in severe COVID-19; leaves open randomized trials before any practice change.
The involvement of the vascular endothelium in the complications of coronavirus disease 2019 is now recognized. Chief among these are pulmonary endotheliitis, cytokine storm, endotoxic shock, and cardiovascular collapse. This Perspectives article is focused on therapeutical strategies to reduce the risk of these complications by targeting the vascular endothelium as a part of the overall treatment of coronavirus disease 2019.
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Suvorava et al. (2020) studied this question.
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