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June 1, 2004Acta Physiologica ScandinavicaOpen Access

Measurement of coronary flow reserve in isolated hearts from mice

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Population

Isolated murine hearts (Langendorff-perfused mouse heart preparation)

Comparison

Vasoactive drugs and short-term no-flow ischaemia vs Baseline values

Design

Preclinical

Follow-up

2-h perfusion period

Authors

SBS. BratkovskyEAEllen AasumCBC. H. Birkeland

Discussion

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Overview

No immediate clinical implications; validates isolated mouse heart model for coronary flow research.

Structured PICO

P
Population
Isolated murine hearts (Langendorff-perfused mouse heart preparation)
I
Intervention
Vasoactive drugs (sodium-nitroprusside, adenosine) and short-term no-flow ischaemia
C
Comparator
Baseline values
O
Outcome
Simultaneous measurement of left ventricular haemodynamics and coronary flow (CF)surrogate

An isolated perfused mouse heart model can reliably measure coronary flow and hemodynamics, demonstrating that coronary flow reserve in this model is relatively small compared to blood-perfused organs.

Cite This Study

Bratkovsky et al. (2004) studied this question.

synapsesocial.com/papers/6a89488aa7eee2293bcaf851https://doi.org/10.1111/j.1365-201x.2004.01280.x
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