Why the study?
Does GRK2 downregulation affect developmental and tumoral vascularization in preclinical models?
Population
Mice hemizygous for Grk2, animals with endothelium-specific Grk2 silencing, mouse embryos with systemic or…
Comparison
Grk2 ablation, silencing, or downregulation vs Wild-type or control animals (implied)
Design
Preclinical
Authors
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Should not alter clinical practice; leaves open GRK2 as a therapeutic target in human tumor angiogenesis.
Does GRK2 downregulation affect developmental and tumoral vascularization in preclinical models?
GRK2 downregulation is a key event in the tumoral angiogenic switch, leading to impaired vessel maturation and accelerated tumor growth.
Carmona et al. (2013) studied this question.
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