What question did this study set out to answer?

To assess bone mineral content and identify skeletal demineralization using direct photon absorptiometry across different pediatric renal conditions.

December 1, 1977PEDIATRICS

Bone Mineral Status Measured by Direct Photon Absorptiometry in Childhood Renal Disease

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Authors

RCRussell W. ChesneyRutgers, The State University of New Jersey RMRichard B. MazessUniversity of Wisconsin–Madison PRPhilip G. RoseSouthampton General Hospital

Discussion

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Implication

Observational study reveals high rates of bone demineralization in children with renal disease, highlighting risks linked to tubulointerstitial disorders and daily steroid therapy.

Key Points

To assess bone mineral content and identify skeletal demineralization using direct photon absorptiometry across different pediatric renal conditions.
Conducted serial direct photon absorptiometry on the radius and ulna to measure bone width (BW) and bone mineral content (BMC) in N=74 children with renal diseases.
Compared BMC and BMC/BW ratios against age-, sex-, height-, and weight-matched healthy controls with a normal variance of ±10% from the mean.
Significant demineralization (> -2 SD) occurred in 42% of all patients and in 75% of those with tubulointerstitial disease, including severe demineralization (> -3 SD) in 4 rachitic patients.
Demineralization was identified in 12 nephrotic syndrome and 2 lupus erythematosus patients treated with prednisone (serum creatinine <1.0 mg/dl), as well as 3 patients treated with anticonvulsants.
BMC declined during daily prednisone therapy but increased on alternate-day regimens in 7 patients, whereas normal mineralization remained in 32 patients with primary glomerular disease.

Cite This Study

Chesney et al. (1977) studied this question.

synapsesocial.com/papers/6a894da85edafe343d92d537 https://doi.org/10.1542/peds.60.6.864

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Implication

Observational study reveals high rates of bone demineralization in children with renal disease, highlighting risks linked to tubulointerstitial disorders and daily steroid therapy.

Bone Mineral Status Measured by Direct Photon Absorptiometry in Childhood Renal Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Bone Mineral Status Measured by Direct Photon Absorptiometry in Childhood Renal Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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