What question did this study set out to answer?

To determine the relationship between serum leptin concentrations, glomerular filtration rate (GFR), and spontaneous energy intake in children with chronic renal failure (CRF).

June 1, 1998Journal of the American Society of Nephrology

Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood.

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Authors

MDM. DaschnerHeidelberg University BTB TönshoffHeidelberg University WBWerner BlumUniversity of Kassel

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Implication

Observational study reveals elevated serum leptin levels in pediatric chronic renal failure, indicating impaired renal clearance may drive decreased appetite and uremic anorexia.

Key Points

To determine the relationship between serum leptin concentrations, glomerular filtration rate (GFR), and spontaneous energy intake in children with chronic renal failure (CRF).
Measured serum leptin by radioimmunoassay and gel chromatography in 134 pediatric patients across various stages of chronic renal failure.
Quantified body fat percentage via skinfold thickness and spontaneous caloric intake from written dietary diaries.
Serum leptin exceeded the 50th percentile of normal in 78% of patients and the 95th percentile in 45%, eluting as a single intact 16 kD peak rather than degradation fragments.
Body fat percentage (r = 0.79, P < 0.0001) and GFR (r = -0.17, P < 0.005) independently predicted serum leptin, explaining 66% of total variance.
Standardized leptin levels (z-scores) showed a significant inverse correlation with spontaneous energy intake (r = -0.36, P < 0.001).

Cite This Study

Daschner et al. (1998) studied this question.

synapsesocial.com/papers/6a894dfb75060194fdc979f2 https://doi.org/10.1681/asn.v961074

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Implication

Observational study reveals elevated serum leptin levels in pediatric chronic renal failure, indicating impaired renal clearance may drive decreased appetite and uremic anorexia.

Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood.

Discussion

Member takes

Implication

Key Points

Cite This Study

Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood.

Discussion

Member takes

Implication

Key Points

Cite This Study

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