Why the study?
Does Sodium Salicylate and Prednisolone therapy improve grip strength in patients with rheumatoid arthritis?
Population
Patients with rheumatoid arthritis
Comparison
Sodium Salicylate and Prednisolone vs Cross-over design
Design
RCT, double-blind
Authors
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Substantial grip strength observer variability questions its reliability as an RA trial endpoint; supports standardized single-observer protocols at consistent times.
Does Sodium Salicylate and Prednisolone therapy improve grip strength in patients with rheumatoid arthritis?
Grip strength measurement in rheumatoid arthritis has significant intra- and inter-observer variability and diurnal variation, requiring standardized measurement protocols by a single observer at the same time of day in clinical trials.
Lee et al. (1974) studied this question.
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