Why the study?
Does limited dose warfarin compared to phenindione prevent failure to achieve target INR in pregnant and non-pregnant patients with mechanical heart valve prosthesis?
Population
200 young females with mitral mechanical heart valve prosthesis, NYHA class I-II, achieving INR during the…
Comparison
Limited dose warfarin (≤5 mg/day) vs Phenindione (≤100 mg/day)
Design
RCT, Randomized in a 3:1 ratio to LDW or phenindione
Follow-up
throughout pregnancy
Authors
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Limited-dose warfarin should be avoided in pregnant patients with mechanical valves; supports phenindione as effective alternative for INR control.
Does limited dose warfarin compared to phenindione prevent failure to achieve target INR in pregnant and non-pregnant patients with mechanical heart valve prosthesis?
Limited dose warfarin (≤5 mg/day) is insufficient to maintain target INR in high-risk pregnant patients with mechanical heart valves, whereas phenindione may offer an effective alternative.
Hassouna et al. (2014) studied this question.
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