Why the study?
Successful clinical application of platelet function tests requires understanding their analytical strengths, limitations, and correct clinical extrapolation to inform bleeding and thrombosis risk.
What is the current role of platelet function testing in clinical practice for assessing bleeding and thrombosis risk?
What is the current role of platelet function testing in clinical practice for assessing bleeding and thrombosis risk?
This review critically appraises traditional and contemporary platelet function testing and their role in clinical practice for assessing bleeding and thrombosis risk.
Platelet function testing should not yet guide routine decisions; leaves open need for validated assays in bleeding and thrombosis assessment.
Platelet dysfunction, whether hereditary or acquired, may increase an individual's risk of spontaneous, posttraumatic, or postoperative bleeding. Conversely, increased platelet reactivity on antiplatelet agents following vascular (in particular, coronary vascular) intervention may increase the risk of thrombosis and adverse vascular events. The aim of platelet function testing is to identify and characterize platelet dysfunction in these settings to inform bleeding/ thrombosis risk and guide perioperative prophylactic management strategies. A vast array of screening and diagnostic tests is available for this purpose. The successful clinical application of platelet function tests depends on the knowledge of their analytical strengths and limitations and the correct extrapolation of derived results to a particular clinical scenario. This review critically appraises traditional and contemporary platelet function testing focusing on their role in clinical practice.
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Mason et al. (2021) studied this question.
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