Studies Concerning Diabetes

The work, of which this paper will give a synopsis, is the continuation of an experimental study of diabetes described in detail elsewhere.1Certain of the results of the previous investigation, bearing on the present topic, may be summarized under the following four headings: Production of Diabetes: Removal of portions of the dog's pancreas produces a lowering of the sugar tolerance. Removal of nine-tenths of the gland results in severe diabetes. When the remnant is larger (for instance, one-eighth), milder types of diabetes result. The course is chronic, extending over months, and the end fatal. Such animals furnish a closer imitation of human diabetes than is produced by total pancreatectomy. Pathologic Anatomy of Diabetes: In the foregoing procedure, duct communication between the pancreatic remnant and the duodenum is preserved. Therefore the acinar tissue does not atrophy, and in some cases it may hypertrophy. The islands of Langerhans show typical