Why the study?
Type 2 diabetes increases the risk of heart failure, and autophagy may be impaired in the diabetic heart, but autophagic status in human diabetic hearts required exploration.
Does type 2 diabetes alter autophagic protein expression in the right atrial appendage tissue of patients undergoing coronary artery bypass graft?
Does type 2 diabetes alter autophagic protein expression in the right atrial appendage tissue of patients undergoing coronary artery bypass graft?
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This study provides the first evidence of decreased cardiac autophagy (diminished LC3 expression) in the right atrial appendage of diabetic patients undergoing CABG, which may relate to their increased risk of heart failure.
Type 2 diabetes potentiates the risk of heart failure. A vital physiologic process, autophagy, may be impaired in the diabetic heart. The purpose of the present work was to explore the autophagic status in the human diabetic heart. Techniques like immunohistochemistry and western blotting were employed to examine the expression of some of the important proteins involved in autophagic machinery. Our brief study reports, for the first time, evidence of decreased cardiac autophagic levels in diabetic patients.
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Rajendran et al. (2023) studied this question.
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