September 22, 2016Cardiovascular DiabetologyOpen Access

Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation

View Full Paper

Ask AI

Bookmark

Population

C57BL/6 male mice subjected to transverse aortic constriction or streptozocin-induced type 1 diabetes, and…

Comparison

Acute hyperglycemia or chronic hyperglycemia; in… vs Sham operation, citrate buffer control, mannitol…

Design

Preclinical

Follow-up

Up to 6 weeks

Authors

JXJiahe XieGannan Medical University KCKai CuiTongji Hospital HHHuixin HaoSouthern Medical University

Discussion

Member takes

Implication

Does not support altering glucose management in hypertrophy; leaves open autophagy's role in human diastolic dysfunction.

Structured PICO

Population

C57BL/6 male mice (9-10 weeks old) subjected to transverse aortic constriction (TAC) or streptozocin-induced type 1 diabetes, and cultured neonatal rat cardiomyocytes.

Intervention

Acute hyperglycemia (glucose 2 g/kg ip) or chronic hyperglycemia (streptozocin 70 mg/kg/day for 5 days); in vitro high glucose (25/50 mmol/L) exposure.

Comparator

Sham operation, citrate buffer control, mannitol injection, or normal glucose (5.5 mmol/L) exposure.

Outcome

Left ventricular diastolic function (LVEDP, tau, dp/dt min) measured by invasive hemodynamics, and autophagic flux (LC3B-II, P62, PGC-1α expression).surrogate

Acute hyperglycemia exacerbates diastolic dysfunction and impairs autophagic flux in hypertrophied hearts, providing a mechanistic link between stress hyperglycemia and poor cardiac outcomes.

Cite This Study

Xie et al. (2016) studied this question.

synapsesocial.com/papers/6a81d979d433ecbb06e1e733 https://doi.org/10.1186/s12933-016-0452-z

View Full Paper

Ask AI

Bookmark