Key result
Streptozotocin-induced diabetes in rats attenuated left ventricular dysfunction 90 days after myocardial infarction but worsened autonomic dysfunction and increased mortality (73% vs 62%) compared to normoglycemic infarcted rats.
Why the study?
Does STZ-induced diabetes alter left ventricular dysfunction, autonomic damage, and mortality after myocardial infarction in rats?
Population
82 adult male Wistar rats (~240 g at baseline)
Comparison
Streptozotocin-induced diabetes followed by… vs Myocardial infarction alone, diabetes alone, and…
Design
Preclinical, Rats were randomly assigned, Echocardiography was performed by a…
Follow-up
90 days after myocardial infarction
Authors
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Hypothesis-generating for divergent post-MI effects of diabetes on LV versus autonomic function; leaves open human translational relevance.
Does STZ-induced diabetes alter left ventricular dysfunction, autonomic damage, and mortality after myocardial infarction in rats?
Absolute Event Rate: 73% vs 62%
p-value: p=<0.05
In a rodent model, chronic hyperglycemia attenuated post-MI left ventricular dysfunction but exacerbated autonomic dysfunction and increased mortality.
Rodrigues et al. (2011) studied Myocardial Infarction and Diabetes Mellitus (n=82). Streptozotocin-induced diabetes (hyperglycemia) vs. Normoglycemia (buffer injection) was evaluated on Mortality rate at 90 days post-myocardial infarction (p=<0.05). Streptozotocin-induced diabetes in rats attenuated left ventricular dysfunction 90 days after myocardial infarction but worsened autonomic dysfunction and increased mortality (73% vs 62%) compared to normoglycemic infarcted rats.
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