Why the study?
Does acute streptozotocin-induced diabetes worsen cardiac remodeling and function in mice after myocardial infarction?
Population
Mice subjected to myocardial infarction (MI) by coronary artery ligation
Comparison
Acute streptozotocin-induced diabetes vs Non-diabetic mice subjected to MI
Design
Preclinical
Follow-up
up to 14 days
Authors
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Diabetes worsens post-MI remodeling in mice; hypothesis-generating and should not yet change practice.
Does acute streptozotocin-induced diabetes worsen cardiac remodeling and function in mice after myocardial infarction?
Acute diabetes exacerbates adverse cardiac remodeling, extracellular matrix degradation, and dysfunction following myocardial infarction in mice.
Eguchi et al. (2012) studied this question.
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