January 1, 2007Cardiovascular DiabetologyOpen Access

Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI).

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Population

8-week old C57BL/6 mice

Comparison

Streptozotocin-induced type 1 diabetes vs Age-matched controls

Design

Preclinical

Follow-up

4 weeks

Authors

XYXichun YuUniversity of Oklahoma Health Sciences Center YTYasvir A. TesiramThe University of Queensland RTRheal A. TownerUniversity of Prince Edward Island

Discussion

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Implication

MRI detects early diabetic cardiomyopathy in mice; leaves open human translation and validation.

Structured PICO

Population

8-week old C57BL/6 mice

Intervention

Streptozotocin-induced type 1 diabetes (blood glucose maintained at 19-25 mmol/l using intermittent low dosages of long acting insulin glargine)

Comparator

Age-matched controls

Outcome

Myocardial morphology and functionality assessed by MRI and echocardiographysurrogate

In vivo MRI can effectively identify the early onset of diabetic cardiomyopathy, including structural and functional deficits, in a mouse model of type 1 diabetes.

Cite This Study

Yu et al. (2007) studied this question.

synapsesocial.com/papers/6a88044d4c82be800eeb396c https://doi.org/10.1186/1475-2840-6-6

Topics

Cardiomyopathy

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Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI).

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI).

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider