Why the study?
Does experimental diabetes induce early changes in myocardial function in a rodent model?
Population
Rats (N=14 total; N=7 diabetic, N=7 control)
Comparison
Streptozotocin induced experimental diabetes vs Control rats
Design
Preclinical
Follow-up
30 days
Authors
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Alerts to early cardiac vulnerability in diabetic models; hypothesis-generating for mechanisms while leaving human translation open.
Does experimental diabetes induce early changes in myocardial function in a rodent model?
Experimental diabetes in rodents induces early systolic and diastolic dysfunction and reduces the capacity for cardiac adjustment to volume overload, which can be effectively evaluated using echocardiography.
Wichi et al. (2007) studied this question.
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