January 16, 2018Cardiovascular DiabetologyOpen Access

Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models

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Why the study?

Does speckle-tracking echocardiography correlate with invasive hemodynamics for detecting cardiac dysfunction in diabetic rat models?

Population

Rat models of type-1 diabetes mellitus and type-2 diabetes mellitus and corresponding control animals

Comparison

Speckle-tracking echocardiography (STE) vs Invasive hemodynamics

Design

Preclinical

Authors

CMCsaba MátyásSemmelweis University AKAttila KovácsSemmelweis University BNBalázs Tamás NémethSemmelweis University

Discussion

Member takes

Implication

Supports noninvasive STE assessment in diabetic rat models; leaves open translation to human diabetes care.

Structured PICO

Does speckle-tracking echocardiography correlate with invasive hemodynamics for detecting cardiac dysfunction in diabetic rat models?

Population

Rat models of type-1 diabetes mellitus (T1DM, induced by 60 mg/kg streptozotocin, n = 8) and type-2 diabetes mellitus (T2DM, 32-week-old Zucker Diabetic Fatty rats, n = 7) and corresponding control animals (n = 5 and n = 8, respectively)

Intervention

Speckle-tracking echocardiography (STE)

Comparator

Invasive hemodynamics (left ventricular pressure-volume analysis)

Outcome

Detection of cardiac dysfunction (systolic and diastolic function parameters)surrogate

Strain and strain rate parameters from speckle-tracking echocardiography are feasible and correlate with invasive hemodynamics for assessing cardiac dysfunction in diabetic rat models.

Cite This Study

Mátyás et al. (2018) studied this question.

synapsesocial.com/papers/6a85124cfbd9f4f9f9bdfd51 https://doi.org/10.1186/s12933-017-0645-0

Topics

Echocardiography

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Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider