Key result
At 16 weeks of age, left ventricular radial strain and circumferential strain were significantly lower in diabetic db/db mice compared to control mice (P < 0.01).
Why the study?
Does speckle tracking echocardiography detect early left ventricular systolic dysfunction better than conventional echocardiography in type II diabetic mice?
Does speckle tracking echocardiography detect early left ventricular systolic dysfunction better than conventional echocardiography in type II diabetic mice?
Absolute Event Rate: 31.19% vs 42.37%
p-value: p=<0.01
Speckle tracking echocardiography can detect early left ventricular contractile dysfunction in type II diabetic mice before conventional echocardiographic parameters show abnormalities.
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Speckle tracking may detect subclinical LV dysfunction in diabetic mice; leaves open translation to human T2DM screening.
Li et al. (2014) studied Type II diabetes / Diabetic cardiomyopathy (n=48). Type II diabetes (db/db mouse model) vs. Age-matched non-diabetic control mice was evaluated on Left ventricular radial strain at 16 weeks of age (p=<0.01). At 16 weeks of age, left ventricular radial strain and circumferential strain were significantly lower in diabetic db/db mice compared to control mice (P < 0.01).
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