Key result
High-fat, high-sugar diet reduces LV peak diastolic strain rate by ~33% in mice.
Why the study?
Validated tools for in vivo monitoring of diastolic function in rodent models of diabetes are required for progress in pre-clinical cardiology studies.
Can 2D speckle tracking echocardiography detect global and regional diastolic dysfunction in a murine model of cardio-metabolic disease?
Population
C57Bl/6 male mice with type 2 diabetes induced by high fat high sugar diet for 20 weeks
Comparison
2D speckle tracking echocardiography assessment of diastolic function
Design
Pre-clinical study
Follow-up
20 weeks
Authors
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Speckle tracking detects diet-induced LV diastolic impairment in mice; supports its use in pre-clinical cardio-metabolic models but leaves clinical translation open.
Can 2D speckle tracking echocardiography detect global and regional diastolic dysfunction in a murine model of cardio-metabolic disease?
Effect estimate: 33% decrease
p-value: p=<0.05
2D speckle tracking echocardiography is a viable tool for comprehensive global and regional assessment of diastolic function in pre-clinical murine models of cardio-metabolic disease.
Daniels et al. (2022) studied Type 2 diabetes and diastolic dysfunction. High fat high sugar diet vs. Control reference diet (16% kcal from fat, 100g/kg sucrose) was evaluated on Longitudinal peak diastolic strain rate (33% decrease, p=<0.05). A high fat high sugar dietary intervention for 20 weeks significantly impaired left ventricle peak diastolic strain rate and velocity in longitudinal and radial planes in mice.
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