Key result
In a rat model, Doppler myocardial imaging detected early radial systolic dysfunction in diabetic rats compared to controls (rate of change in radial systolic velocity -0.003 vs. +0.01 week(-1); P<0.01).
Why the study?
Does Doppler myocardial imaging detect early systolic left ventricular dysfunction in a rat model of diabetic cardiomyopathy?
Population
20 rats (12 Streptozotocin-induced diabetic rats and 8 control rats)
Comparison
Doppler myocardial imaging including velocity… vs Control rats and conventional M-mode…
Design
Preclinical
Follow-up
16 weeks
Authors
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Supports preclinical exploration of Doppler myocardial imaging; leaves open translation to human diabetic cardiomyopathy detection.
Does Doppler myocardial imaging detect early systolic left ventricular dysfunction in a rat model of diabetic cardiomyopathy?
Absolute Event Rate: -0.003% vs 0.01%
p-value: p=<0.01
Doppler myocardial imaging can detect early radial systolic dysfunction in a diabetic cardiomyopathy model before changes in ejection fraction or histological fibrosis become apparent.
Weytjens et al. (2008) studied Diabetic cardiomyopathy (n=20). Streptozotocin (STZ)-induced diabetes vs. Control rats was evaluated on Radial systolic velocity rate of change (week^-1) (p=<0.01). In a rat model, Doppler myocardial imaging detected early radial systolic dysfunction in diabetic rats compared to controls (rate of change in radial systolic velocity -0.003 vs. +0.01 week(-1); P<0.01).
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