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April 20, 2010European Journal of Heart FailureOpen Access

Hyperglycaemia Protects the Heart After Myocardial Infarction: Aspects of Programmed Cell Survival and Cell Death

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Key result

Chronic diabetic hyperglycaemia improved systolic function and reduced myocardial infarction size by 36% in rats 15 days post-MI, accompanied by increased angiogenesis and reduced fibrosis.

Why the study?

Does chronic diabetic hyperglycemia protect the heart against ischemic injury after myocardial infarction in a rat model?

Population

Male Wistar rats

Comparison

Chronic diabetic hyperglycemia prior to… vs Non-diabetic myocardial infarction…

Design

Preclinical

Follow-up

15 days post-MI

Authors

CMChristiane MalfitanoTLTatiana Carolina Alba LoureiroBRBruno Rodrigues

Discussion

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Member takes

Overview

Hyperglycaemia may protect diabetic rat hearts post-MI; leaves open human translation.

Structured PICO

Does chronic diabetic hyperglycemia protect the heart against ischemic injury after myocardial infarction in a rat model?

P
Population
32 male Wistar rats divided into control, diabetic, myocardial infarcted, and diabetic myocardial infarcted groups, assessed 15 days post-MI.
E
Exposure
Chronic diabetic hyperglycemia (diabetes model) prior to myocardial infarction
C
Comparator
Non-diabetic myocardial infarction, non-infarcted diabetic, and non-infarcted control groups
O
Outcome
Cardiac function, programmed cell survival, and cell death (including MI size, echocardiographic function, cytokines, gene expression, caspase-3 activity, GLUT protein expression, capillary density, and fibrosis) assessed 15 days post-MIsurrogate

Main Result

Effect estimate: 36% reduction

In a rat model, chronic diabetic hyperglycemia appears to confer cellular resistance to ischemic injury and greater plasticity post-myocardial infarction.

Cite This Study

Malfitano et al. (2010) studied Myocardial infarction (n=32). Hyperglycaemia (diabetes) vs. Normoglycaemia (non-diabetic) was evaluated on Myocardial infarction size (36% reduction). Chronic diabetic hyperglycaemia improved systolic function and reduced myocardial infarction size by 36% in rats 15 days post-MI, accompanied by increased angiogenesis and reduced fibrosis.

synapsesocial.com/papers/6a6c15b36f523709a024f003https://doi.org/10.1093/eurjhf/hfq053
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors2014 · 8 citations
  2. 2Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats2014 · 29 citations
  3. 3Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents2011 · 12 citations
  4. 4Detrimental effects of acute hyperglycaemia on the rat heart2013 · 38 citations
  5. 5Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents2011 · 32 citations