Why the study?
Does hexarelin or growth hormone improve recovery of postischemic left ventricular developed pressure in senescent rat hearts?
Population
24-month-old male rats with senescent hearts subjected to moderate ischemia (n=25)
Comparison
Hexarelin or Growth Hormone administered in vivo… vs Control (saline-treated) senescent rats
Design
Preclinical
Follow-up
21 days
Authors
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Should not change practice; leaves open whether hexarelin's direct effects exceed GH in human postischemic recovery.
Does hexarelin or growth hormone improve recovery of postischemic left ventricular developed pressure in senescent rat hearts?
Hexarelin displays strong cardioprotective activity against myocardial stunning in senescent rats, which is greater than that of growth hormone and likely due to a direct cardiotropic action.
Rossoni et al. (1998) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: