Experimental study demonstrates room-temperature palladium-catalyzed aminocarbonylation of aryl and alkenyl iodides with nitroarenes, highlighting an efficient route to synthesize substituted amides.
A visible-light-promoted palladium-catalyzed aminocarbonylation of aryl and alkenyl iodides with nitroarenes using Mo(CO)6 as the CO source has been developed. This newly developed reductive aminocarbonylation reaction operates efficiently at ambient temperature (25 °C) in the absence of an external photocatalyst. Both aryl and alkenyl iodides were suitable substrates, providing access to a wide range of substituted amides in good to excellent yields. The exceptionally mild reaction conditions significantly improve functional group compatibility, thereby expanding the substrate scope of this transformation.
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Li et al. (2026) studied this question.
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