What does this research mean for the field?

Although the Mindray BC-7800/BC-7900 and Sysmex XN-9100 hematology platforms demonstrate excellent analytical agreement for routine complete blood counts, they exhibit distinct automated morphological flagging profiles, indicating that comparable analytical performance does not guarantee identical morphological interpretation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the analytical performance and algorithm-assisted morphological flagging of the Mindray BC-7800/BC-7900 and Sysmex XN-9100 hematology analyzers under routine laboratory conditions.

August 22, 2026DiagnosticsOpen Access

Beyond Analytical Agreement: Integrating Analytical Performance and Algorithm-Assisted Morphological Interpretation in a Comparative Evaluation of the Mindray BC-7800/BC-7900 and Sysmex XN-9100 Hematology Platforms

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Authors

SMSara Ciullini MannuritaAzienda Ospedaliero-Universitaria Careggi DRDomenico RomeoAzienda Ospedaliero-Universitaria Careggi ABAlessandro BonariAzienda Ospedaliero-Universitaria Careggi

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Implication

Comparative study reveals high analytical agreement but distinct morphological flagging in peripheral blood samples, highlighting the need to evaluate flagging algorithms.

Key Points

To compare the analytical performance and algorithm-assisted morphological flagging of the Mindray BC-7800/BC-7900 and Sysmex XN-9100 hematology analyzers under routine laboratory conditions.
Analyzed 183 peripheral blood samples from healthy individuals and patients with hematological and non-hematological disorders in parallel across both platforms.
Evaluated analytical agreement for complete blood count and leukocyte differential parameters using Passing–Bablok regression and Bland–Altman analyses.
Assessed automated morphological flagging across 157 samples against expert optical microscopy as the reference standard.
Principal complete blood count parameters exhibited correlation coefficients ranging from 0.981 to 1.000 with minimal proportional bias, though monocytes, eosinophils, and basophils showed higher variability at low concentrations.
Both platforms achieved negative predictive values exceeding 90%, while agreement with expert microscopy ranged from fair to moderate for most pathological flag categories.

Cite This Study

Mannurita et al. (2026) studied this question.

synapsesocial.com/papers/6a895ec3ca7ade938187cd9a https://doi.org/10.3390/diagnostics16162642

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Implication

Comparative study reveals high analytical agreement but distinct morphological flagging in peripheral blood samples, highlighting the need to evaluate flagging algorithms.

Beyond Analytical Agreement: Integrating Analytical Performance and Algorithm-Assisted Morphological Interpretation in a Comparative Evaluation of the Mindray BC-7800/BC-7900 and Sysmex XN-9100 Hematology Platforms

Discussion

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Implication

Key Points

Cite This Study

Beyond Analytical Agreement: Integrating Analytical Performance and Algorithm-Assisted Morphological Interpretation in a Comparative Evaluation of the Mindray BC-7800/BC-7900 and Sysmex XN-9100 Hematology Platforms

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Key Points

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