What does this research mean for the field?

Bioactive compounds in Allium sativum L., particularly N-trans-feruloyltramine, exhibit computationally predicted stable binding affinity for the dopamine D2 receptor, suggesting potential relevance for dopaminergic signaling. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Investigate the binding affinities and molecular interactions of Allium sativum phytochemicals against the dopamine D2 and serotonin 5-HT2A receptors implicated in bipolar disorder.

August 22, 2026Journal of Receptors and Signal Transduction

Computational identification of Allium sativum phytochemicals with predicted binding to the dopamine D2 receptor relevant to bipolar disorder

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Authors

MPMurat Kaan Pekgoz TÇTunç Çatal BABelkıs Atasever-Arslan

Discussion

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Overview

Computational study reveals selective binding of Allium sativum phytochemicals to dopamine D2 receptors, suggesting potential therapeutic candidates for bipolar disorder.

Key Points

Investigate the binding affinities and molecular interactions of Allium sativum phytochemicals against the dopamine D2 and serotonin 5-HT2A receptors implicated in bipolar disorder.
Conducted in silico computational modeling and molecular docking to evaluate bioactive compounds from Allium sativum L.
Assessed predicted ligand interactions and structural stability against both dopamine D2 receptors (D2DR) and serotonin 5-HT2A receptors (HT2AR).
Allium sativum bioactive compounds demonstrated high predicted binding affinity for the dopamine D2 receptor, with markedly lower affinity observed for the serotonin 5-HT2A receptor.
N-trans-feruloyltramine was identified as a prioritized candidate possessing a structurally stable binding affinity for the dopamine D2 receptor.

Cite This Study

Pekgoz et al. (2026) studied this question.

synapsesocial.com/papers/6a895ec3ca7ade938187ce9d https://doi.org/10.1080/10799893.2026.2718727

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August 22, 2026Journal of Receptors and Signal Transduction

Computational identification of Allium sativum phytochemicals with predicted binding to the dopamine D2 receptor relevant to bipolar disorder

View Full Paper

Ask AI

Bookmark

Authors

MPMurat Kaan Pekgoz TÇTunç Çatal BABelkıs Atasever-Arslan

Discussion

Member takes

Overview

Computational study reveals selective binding of Allium sativum phytochemicals to dopamine D2 receptors, suggesting potential therapeutic candidates for bipolar disorder.

Key Points

Investigate the binding affinities and molecular interactions of Allium sativum phytochemicals against the dopamine D2 and serotonin 5-HT2A receptors implicated in bipolar disorder.
Conducted in silico computational modeling and molecular docking to evaluate bioactive compounds from Allium sativum L.
Assessed predicted ligand interactions and structural stability against both dopamine D2 receptors (D2DR) and serotonin 5-HT2A receptors (HT2AR).
Allium sativum bioactive compounds demonstrated high predicted binding affinity for the dopamine D2 receptor, with markedly lower affinity observed for the serotonin 5-HT2A receptor.
N-trans-feruloyltramine was identified as a prioritized candidate possessing a structurally stable binding affinity for the dopamine D2 receptor.

Cite This Study

Pekgoz et al. (2026) studied this question.

synapsesocial.com/papers/6a895ec3ca7ade938187ce9d https://doi.org/10.1080/10799893.2026.2718727

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