Fibrosing Skin Disorder Associated With Zilucoplan

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Zilucoplan may be associated with the development of a fibrosing skin disorder, characterized by progressive induration and fibrosis, in patients being treated for myasthenia gravis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Alexandre Auroy; Eiryann Humbert; Julien Praline; Thibault Kervarrec; M. Samimi

doi:10.1001/jamadermatol.2026.2321

August 19, 2026JAMA Dermatology

Fibrosing Skin Disorder Associated With Zilucoplan

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Key Points

To document a case of a progressive fibrosing skin disorder associated with zilucoplan therapy in severe, refractory myasthenia gravis.
Clinical evaluation and case documentation of a female patient with severe, refractory myasthenia gravis who developed dermatological complications during zilucoplan treatment.
The patient developed progressive induration and fibrosis of the skin localized to the trunk and proximal extremities.

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Implication

Case report describes progressive skin fibrosis and induration in a patient receiving zilucoplan for myasthenia gravis, highlighting a potential adverse dermatological reaction.

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Cite This Study

Auroy et al. (2026) studied this question.

synapsesocial.com/papers/6a895effca7ade938187d3a6 https://doi.org/10.1001/jamadermatol.2026.2321

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Fibrosing Skin Disorder Associated With Zilucoplan

Key Points

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Implication

Abstract

Discussion

Cite This Study

Fibrosing Skin Disorder Associated With Zilucoplan

Key Points

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Implication

Abstract

Discussion

Cite This Study

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