What does this research mean for the field?

Double filtration plasmapheresis (DFPP) is associated with short-term functional improvement in patients with Guillain-Barré syndrome, with no significant difference in short-term efficacy compared to IVIG alone or DFPP combined with corticosteroids. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the real-world short-term functional outcomes and immunological biomarker changes in patients with Guillain–Barré syndrome treated with double filtration plasmapheresis regimens.

August 22, 2026Therapeutic Apheresis and Dialysis

Clinical Outcomes of Double Filtration Plasmapheresis in Guillain–Barré Syndrome: A Single‐Center Retrospective Study

View Full Paper

Ask AI

Bookmark

Authors

JLJingwen LiRenji Hospital YCYing ChenRenji Hospital JWJun WuRenji Hospital

Discussion

Member takes

Implication

Retrospective study demonstrates functional recovery with double filtration plasmapheresis in Guillain–Barré syndrome, suggesting short-term efficacy comparable to standard therapies.

Key Points

To evaluate the real-world short-term functional outcomes and immunological biomarker changes in patients with Guillain–Barré syndrome treated with double filtration plasmapheresis regimens.
Retrospective single-center study of N=43 patients with Guillain–Barré syndrome treated between June 2018 and October 2024.
Compared 36 patients receiving double filtration plasmapheresis (DFPP) regimens (alone or combined with intravenous methylprednisolone) against 7 patients receiving intravenous immunoglobulin (IVIG) alone.
Measured pre- and post-treatment functional scores using the modified Rankin Scale (mRS) and Hughes functional grading scale (HFGS), alongside changes in serum immunoglobulins (IgG, IgA, IgM) and complement levels.
mRS and HFGS scores improved significantly from baseline to discharge across all treatment arms (DFPP alone, DFPP plus methylprednisolone, and IVIG alone).
No statistically significant differences in functional score changes were observed between DFPP alone versus IVIG alone, or between DFPP alone versus DFPP combined with methylprednisolone.
DFPP significantly lowered serum immunoglobulin and complement concentrations, but the percentage reductions in IgG, IgA, and IgM did not correlate significantly with short-term functional score improvements.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a895effca7ade938187d3d8 https://doi.org/10.1002/1744-9987.70211

View Full Paper

Ask AI

Bookmark

August 22, 2026Therapeutic Apheresis and Dialysis

Clinical Outcomes of Double Filtration Plasmapheresis in Guillain–Barré Syndrome: A Single‐Center Retrospective Study

View Full Paper

Ask AI

Bookmark

Authors

JLJingwen LiRenji Hospital YCYing ChenRenji Hospital JWJun WuRenji Hospital

Discussion

Member takes

Implication

Retrospective study demonstrates functional recovery with double filtration plasmapheresis in Guillain–Barré syndrome, suggesting short-term efficacy comparable to standard therapies.

Key Points

To evaluate the real-world short-term functional outcomes and immunological biomarker changes in patients with Guillain–Barré syndrome treated with double filtration plasmapheresis regimens.
Retrospective single-center study of N=43 patients with Guillain–Barré syndrome treated between June 2018 and October 2024.
Compared 36 patients receiving double filtration plasmapheresis (DFPP) regimens (alone or combined with intravenous methylprednisolone) against 7 patients receiving intravenous immunoglobulin (IVIG) alone.
Measured pre- and post-treatment functional scores using the modified Rankin Scale (mRS) and Hughes functional grading scale (HFGS), alongside changes in serum immunoglobulins (IgG, IgA, IgM) and complement levels.
mRS and HFGS scores improved significantly from baseline to discharge across all treatment arms (DFPP alone, DFPP plus methylprednisolone, and IVIG alone).
No statistically significant differences in functional score changes were observed between DFPP alone versus IVIG alone, or between DFPP alone versus DFPP combined with methylprednisolone.
DFPP significantly lowered serum immunoglobulin and complement concentrations, but the percentage reductions in IgG, IgA, and IgM did not correlate significantly with short-term functional score improvements.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a895effca7ade938187d3d8 https://doi.org/10.1002/1744-9987.70211

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark