Review demonstrates soft bioelectronic platforms for continuous sensing and targeted therapy in dynamic skin wounds, highlighting the promise of autonomous closed-loop wound management.
Key Points
To review the underlying principles, diagnostic sensor mechanisms, therapeutic modalities, and integrated system architectures of soft bioelectronics for comprehensive wound care.
Synthesized biophysical and biochemical sensing mechanisms designed to capture critical physiological parameters within dynamic wound microenvironments.
Evaluated soft therapeutic strategies, including electrical, photothermal, and acoustic stimulation, alongside microenvironment-responsive drug delivery architectures in open-loop and closed-loop formats.
Soft bioelectronics successfully interface intimately with skin to enable real-time multimodal diagnostic tracking combined with wireless data communication.
Integrated closed-loop platforms enable on-demand transdermal therapy triggered by local microenvironmental cues, though long-term operational stability remains an ongoing challenge.