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August 22, 2026Gut MicrobesOpen Access

Early-life gut dysbiosis programs divergent metabolic trajectories in a sex-dependent manner

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Authors

JSJunlei SuYGYunchong GuoLSLijun Shen

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Overview

Animal study demonstrates that early-life antibiotic exposure programs sex-divergent metabolic dysfunction in mice, indicating the therapeutic value of timely microbiome restoration.

Key Points

  • To investigate how transient early-life antibiotic exposure impacts metabolic programming and liver health in male and female mice.
  • Exposed immature male and female mice to short-term antibiotics followed by a high-fat diet challenge to assess sex-specific metabolic outcomes.
  • Profiled microbiota composition and circulating metabolites, identifying key bacterial taxa and metabolic intermediaries.
  • Administered timely fecal microbiota transplantation to determine if early microbiome restoration could reverse the adverse metabolic phenotype.
  • Early-life antibiotic exposure reduced gonadal white adipose tissue mass and exacerbated high-fat diet-induced hepatic steatosis in male mice, whereas female mice exhibited metabolic protection.
  • Identified dimethylarsinous acid as a key gut-derived metabolite inversely correlated with adipose tissue mass and the abundance of Muribaculum gordoncarteri and Ligilactobacillus apodemi in males.
  • Timely fecal microbiota transplantation successfully reversed the antibiotic-induced metabolic alterations and liver steatosis susceptibility in male mice.

Cite This Study

Su et al. (2026) studied this question.

synapsesocial.com/papers/6a895effca7ade938187d415https://doi.org/10.1080/19490976.2026.2718681
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Also Consider

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  1. 1Early postnatal antibiotic-associated gut microbiota alterations might promote long-term lipid metabolism via brown adipose tissue metabolic programming2026
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  5. 5Influences of ampicillin exposure in early life on the murine gut microbiota and steatotic liver disease associated with western diet2026 · 1 citations