Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 25, 2026The Journal of Medical InvestigationOpen Access

Influences of ampicillin exposure in early life on the murine gut microbiota and steatotic liver disease associated with western diet

View Full Paper
Ask AI
Bookmark
Share

Authors

RIRyuji IshikawaMNMaki NakamuraASAkiko Sakurai

Discussion

Loading...

Member takes

Overview

Randomized trial examines ampicillin’s effects on gut microbiota and liver disease in mice, indicating lasting impacts.

Key Points

  • This study aims to investigate how early life exposure to ampicillin affects gut microbiota and contributes to metabolic dysfunction-associated steatotic liver disease.
  • C57BL/6J mice were exposed to ampicillin in early life and fed a western diet.
  • Fecal microbiota composition was analyzed using 16S metagenome sequencing.
  • Histological evaluations were conducted to assess steatosis and lobular inflammation in the liver.
  • Female mice exposed to ampicillin showed significant steatosis (high NAS score) compared to controls.
  • AMP-treated mice exhibited decreased α-diversity in gut microbiota at 4 weeks, persisting beyond the diet period.
  • α-Diversity negatively correlated with steatohepatitis and fibrosis scores.

Cite This Study

Ishikawa et al. (2026) studied this question.

synapsesocial.com/papers/69ec593e88ba6daa22dab40ahttps://doi.org/10.2152/jmi.73.186
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early-life gut dysbiosis programs divergent metabolic trajectories in a sex-dependent manner2026
  2. 2Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response2024 · 12 citations
  3. 3Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response2024 · 2 citations
  4. 4Early-Life High-Fat-Diet Exposure Induced Pre-Puberty Obesity-Related MASLD via Autophagy-Mediated Ferroptosis in Male C57BL/6J Mice2026
  5. 5Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease2025 · 5 citations