Patent analysis demonstrates that domain familiarity reduces breakthrough innovation from diverse AI stars in medical R&D, suggesting deep domain experience can hinder novel discoveries.
While artificial intelligence (AI) is expected to drive paradigm-shifting transformations, many initiatives result in merely incremental optimization. Anchored in strategic human capital theory, this study shifts the analytical focus from the scale of elite technical talent, conceptualized as AI stars, to the configuration of their knowledge structures to unpack this paradox. Using a dataset of 1270 medical AI patents from corporate R&D teams, we employed high-dimensional fixed-effects models to examine these dynamics. The results reveal that while the knowledge diversity of AI stars acts as a potent engine for breakthrough innovation, this generative capacity is attenuated by excessive domain familiarity. Specifically, direct domain familiarity (derived from internal experience) and indirect domain familiarity (absorbed through external collaborative networks) negatively moderate this relationship, a dynamic theorized to operate through internal cognitive entrenchment and external relational conformity, respectively. Extending the efficiency-driven consensus regarding bilingual expertise, these findings demonstrate that excessive domain embeddedness transforms from an informational bridge into a restrictive constraint during paradigm-shifting innovations, particularly within highly institutionalized environments.
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Li et al. (2026) studied this question.
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