Key result
TAVI is associated with similar rates of 3-month cognitive preservation compared to SAVR.
Why the study?
Although TAVI and SAVR improve quality of life in patients with severe AS, evidence on post-treatment cognitive recovery remains limited.
Does transcatheter aortic valve implantation improve cognitive status at 3 months compared to surgical aortic valve replacement in older adults with severe aortic stenosis?
Cohort (n=103)
No
Does transcatheter aortic valve implantation improve cognitive status at 3 months compared to surgical aortic valve replacement in older adults with severe aortic stenosis?
Absolute Event Rate: 93.9% vs 91.4%
p-value: p=0.455
In older adults with severe aortic stenosis, short-term cognitive trajectories at 3 months did not significantly differ between TAVI and SAVR, despite TAVI patients having greater baseline age and frailty.
Similar 3-month cognitive trajectories after TAVI or SAVR despite frailty differences; leaves open need for randomized confirmation on longer-term effects.
Background: Cognitive impairment affects approximately 50 million people worldwide, including 5-8% of adults aged over 60 years.This condition is common in patients with severe aortic stenosis (AS).Although both transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) improve the quality of life, evidence on post-treatment cognitive recovery remains limited.Objective: The objective of the study is to analyze differences in cognitive status among older adults with severe AS undergoing TAVI or SAVR 3 months after intervention.Material and methods: An observational, retrospective cohort study was conducted including patients ≥ 70 years of age with severe AS treated with TAVI or SAVR (2023-2024).Comprehensive geriatric assessment and Mini-Mental State Examination (MMSE) scores were obtained from medical records and reassessed after 3 months.Statistical analyses were performed using the Statistical Package for the Social Sciences version 25.Results: A total of 103 patients were included (70 SAVR and 33 TAVI).Sex distribution was similar (p = 0.592).Patients who underwent TAVI were older (80.6 ± 6.2 vs. 74.8± 3.2 years; p < 0.001) and more frequently frail (48.5 vs. 25.7%;p = 0.022) or had suspected sarcopenia (57.6 vs. 35.7%;p = 0.036).No significant differences were observed in the MMSE scores between the groups.Conclusions: Despite the greater age, frailty, and sarcopenia in the TAVI group, cognitive trajectories at 3 months did not significantly differ from those in SAVR patients.
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Gómez-García et al. (2026) conducted a cohort in Severe aortic stenosis (n=103). Transcatheter aortic valve implantation (TAVI) vs. Surgical aortic valve replacement (SAVR) was evaluated on No cognitive impairment at 3 months (assessed via MMSE) (p=0.455). Transcatheter aortic valve implantation resulted in similar rates of preserved cognitive function at 3 months compared to surgical aortic valve replacement (93.9% vs. 91.4%, p=0.455) in older adults with severe aortic stenosis.
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