Effect of Devivit Carnitine on Nonspecific Resistance of Rats Under Toxic Liver Injury

Toxic liver injury is one of the important problems of modern veterinary medicine because hepatic dysfunction is accompanied not only by metabolic disorders but also by systemic changes in the antioxidant and immune systems.The liver plays a central role in detoxification, metabolism, and maintenance of homeostasis.Therefore, exposure to hepatotoxic compounds can lead to oxidative stress, damage to hepatocyte membranes, accumulation of toxic metabolites, and disturbances in both humoral and cellular mechanisms of nonspecific resistance [1][2][3][4][5].Carbon tetrachloride (CCl₄) is widely used for experimental modelling of toxic liver injury.Its biotransformation in hepatocytes with the participation of the cytochrome P450 system results in the formation of highly reactive free radicals [2].These compounds initiate lipid peroxidation, promote membrane damage and contribute to the development of oxidative stress.Such changes are closely associated with alterations in immune reactivity and functional activity of immunocompetent cells.An important direction in the correction of hepatotoxic disorders is the use of complex preparations containing substances with antioxidant, metabolic, and immunomodulatory properties.In this context, particular interest is focused on preparations containing carnitine, vitamin E, vitamin B₁₂, methionine, selenium, and zinc [6].These biologically active substances are involved in energy metabolism, antioxidant protection, stabilization of cell membranes, and regulation of immune responses.The aim of the study was to determine the effect of the complex preparation "Devivit Carnitine" on the parameters of nonspecific resistance in rats under conditions of carbon tetrachloride-induced toxic liver injury.