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August 17, 2025Journal of Complementary and Alternative Medical Research

Reversal of Chemical Potentiated Multiple End Organ Injuries by Citrus reticulata Leaf Extract

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Authors

RARotimi Sunday AjaniOOOnyinyechukwu Thelma. Onuorah

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Overview

This study demonstrates reversal of liver injury in animals induced by carbon tetrachloride, suggesting citrus leaf extract's protective role.

Key Points

  • Oral administration of citrus reticulata leaf extract reversed liver damage induced by carbon tetrachloride, showing potential therapeutic effects.
  • The alanine aminotransferase level in the high dose extract group was comparable to control, indicating effective liver protection.
  • Histopathological evaluation revealed preservation of liver and kidney architecture, affirming extract's safety.
  • Low doses of citrus reticulata extract improved global protein levels, suggesting enhanced immune status in treated animals.

Cite This Study

Ajani et al. (2025) studied this question.

synapsesocial.com/papers/68a36a480a429f797332ebadhttps://doi.org/10.9734/jocamr/2025/v26i8697
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cymbopogon citratus Leaf Extract Mitigates Hepatorenal Injury in Carbon Tetrachloride and Rifampicin-Exposed Rats2024
  2. 2Effects of Ethanol Extract of Tetrapleura tetraptera Fruit on Liver Antioxidant Profile in Albino Rats Intoxicated with Carbon Tetrachloride2025
  3. 3<scp> <i>Citrus depressa</i> </scp> peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation2026 · 1 citations
  4. 4Experimental Evaluation of Hepatoprotective Effect of the Roots of Calotropis gigantean and betel leaf Extract in Wistar rats Against Carbon Tetrachloride Induced Hepatic Damage2025
  5. 5Hepatoprotective activity of aqueous &lt;i&gt;Curcuma longa&lt;/i&gt; rhizome extract against carbon tetrachloride-induced liver toxicity in adult Wistar rats2024