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September 28, 2025Research Journal of Pharmacy and Technology

Experimental Evaluation of Hepatoprotective Effect of the Roots of Calotropis gigantean and betel leaf Extract in Wistar rats Against Carbon Tetrachloride Induced Hepatic Damage

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Authors

JDJayshree Shriram DawaneSNSheetal NijhawanSSSS Sonawane

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Overview

Experimental analysis reveals protective effects against hepatic damage in Wistar rats, suggesting viable natural remedies.

Key Points

  • Significant reduction in serum ALT, AST, ALP, and bilirubin levels indicates hepatoprotective effects.
  • Biochemical markers assessment shows that both extracts reduce liver damage induced by carbon tetrachloride.
  • Histopathological examination confirms improved liver architecture with less necrosis in treated groups.
  • The findings highlight the potential of Calotropis gigantea and betel leaf extracts as liver damage remedies.

Cite This Study

Dawane et al. (2025) studied this question.

synapsesocial.com/papers/68d90bc641e1c178a14f6d79https://doi.org/10.52711/0974-360x.2025.00618
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hepatoprotective Effect of Ethanolic Extract of Cnestis ferruginea Roots on Carbon tetrachloride-Induced Liver Damage in Male Rats2024
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  3. 3Hepatoprotective effect of methanolic leaf extract of Boswelliadalzielii hutchon carbon tetrachloride induced hepatotoxicity in wistar rats2012
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  5. 5Hepatoprotective Effect of Ethanol Extract of Chinese Betel Herb (<I>Peperomia pellucida</I> (L.)) On CCl4-Induced Hepatotoxicity in Experimental Animals2025 · 4 citations