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July 22, 2024Asian Journal of Research in Medical and Pharmaceutical SciencesOpen Access

Prophylactic Effects of Methanolic Leaf Extract of Momordica balsamina Against CCL4 Induced Liver Injury in Wistar Rats

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Authors

BAB AbubakarMYMohammed Haruna YelduWUWawan Junaidi Usman

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Overview

Controlled trial reveals that Momordica balsamina extract prevents carbon tetrachloride-induced liver injury in rats, suggesting potential as an accessible hepatoprotective agent.

Key Points

  • Methanolic leaf extract of Momordica balsamina significantly reduced carbon tetrachloride-induced hepatic damage and normalized liver biomarkers in a dose-dependent manner.
  • Serum malondialdehyde and transaminase levels decreased significantly (P<0.05), while total protein increased with notable hepatocyte recovery at 1500 mg/kg.
  • Controlled laboratory trial across 42 Wistar rats assessed three extract doses over four weeks—rat model; further preclinical and clinical validation is required.

Cite This Study

Abubakar et al. (2024) studied this question.

synapsesocial.com/papers/68e5f858b6db64358758cdaehttps://doi.org/10.9734/ajrimps/2024/v13i3266
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Mixture of Aqueous and Methanolic Extracts of &lt;i&gt;Momordica Balsamina&lt;/i&gt; on Albino Rat Induced2024
  2. 2Hepatoprotective effect of methanolic leaf extract of Boswelliadalzielii hutchon carbon tetrachloride induced hepatotoxicity in wistar rats2012
  3. 3Study the hepatoprotective effect of the methanolic extract of Plumbago auriculata Lam. against CCl4-induced hepatocyte damage in mice2024 · 1 citations
  4. 4Influence of cooking and fractionation of Momordica balsamina L. (Cucurbitaceae) leaves on hypolipidemic and antioxidant properties in rats fed a high-fat diet2026
  5. 5Experimental Evaluation of Hepatoprotective Effect of the Roots of Calotropis gigantean and betel leaf Extract in Wistar rats Against Carbon Tetrachloride Induced Hepatic Damage2025