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March 12, 2026Open Access

Hepatoprotective effect of methanolic leaf extract of Boswelliadalzielii hutchon carbon tetrachloride induced hepatotoxicity in wistar rats

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Authors

DOD. A. OnorioseAUA. A. UwakweCMC. C. Monago

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Overview

Experiments demonstrate the hepatoprotective effects of Boswellia dalzielii in rats, suggesting its potential as a natural remedy for liver damage.

Key Points

  • This research aims to evaluate the hepatoprotective effects of methanolic leaf extract of Boswellia dalzielii against CCl4 induced liver toxicity in rats.
  • Divided 96 male Wistar rats into 7 groups, each receiving different concentrations of the methanolic extract (100mg/kg, 200mg/kg, and 300mg/kg) for 4 weeks.
  • Induced hepatotoxicity using 0.63ml/kg body weight of carbon tetrachloride (CCl4).
  • Measured liver function enzymes including ALT, AST, and ALP alongside total protein and bilirubin levels.
  • Conducted histological examinations of liver sections to confirm biochemical findings.
  • Administration of Boswellia dalzielii extract showed a dose-dependent reduction in liver enzyme levels indicating hepatoprotection.
  • The extract's effects were comparable to the standard hepatoprotective drugs, reducdyn and vitamin E.
  • Histological analyses supported the biochemical improvements, showing less liver damage with higher extract concentrations.

Cite This Study

Onoriose et al. (2012) studied this question.

synapsesocial.com/papers/69b257a296eeacc4fcec675chttps://doi.org/10.5281/zenodo.18921612
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