Imaging in Neuro-Melioidosis: Lessons from a Multi-centre Collaborative Effort Across India

Q: What does this research mean for the field?

Neuro-melioidosis produces extensive craniospinal disease characterized by a disproportionately high frequency of brainstem, tract-based, and spinal involvement relative to other bacterial CNS infections. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sabha Ahmed; Ankit Arora; Srinivas Meharwade; Babu Peter Sathyanathan; Anuradha Kaushik; Anita Mahadevan; V H Ganaraja; DV Seshagiri; Shravan Reddy K; Sai Kant Deepalam; Raghunandan Nadig; Thomas Mathew; Ullas V. Acharya; M Netravathi; Jitender Saini; Maya Bhat; B S Shalini; Sarbesh Tiwari; J Akash; Richa Singh Chauhan; Nihar Kathrani; Shreyas Reddy K; Seetha Lekshmi Bhadran; Joydeep Samanta; Girish Bathla

doi:10.3174/ajnr.a9601

Key Points

To characterize the craniospinal MRI spectrum of neuro-melioidosis and identify recurrent imaging patterns linked to diagnostic delay across multiple tertiary care centers in India.
Retrospective multicentre case series of 33 patients with microbiologically confirmed neuro-melioidosis across seven Indian tertiary centres between 2019 and 2025.
Neuroimaging was evaluated via a predefined 40-variable template assessing lesion distribution, white matter tracts, diffusion restriction, susceptibility-weighted imaging (SWI), enhancement, meningeal involvement, and spinal disease.
Supratentorial disease occurred in 81.8% (27/33), infratentorial disease in 60.6% (20/33), brainstem involvement in 57.6% (19/33), and spinal involvement in 42.4% (14/33), with simultaneous brainstem and intramedullary disease in 33.3% (11/33).
White matter tract dissemination was present in 66.7% (22/33), corticospinal tract involvement in 63.6% (21/33), and the tunnel sign in 57.6% (19/33); diffusion restriction occurred in 72.7% (24/33) and SWI hemorrhage/microbleeds in 36.4% (12/33).
Initial misdiagnosis affected 24.2% (8/33) of patients, 30.3% (10/33) received corticosteroids prior to diagnosis, and in-hospital mortality reached 12.1% (4/33).

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Multicentre retrospective case series reveals prominent brainstem, tract-based, and spinal lesions in neuro-melioidosis, suggesting distinct MRI patterns can aid prompt identification.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Ahmed et al. (2026) studied this question.

synapsesocial.com/papers/6a895f41ca7ade938187db7d https://doi.org/10.3174/ajnr.a9601

View Full Paper

Ask AI

Bookmark

Share

Imaging in Neuro-Melioidosis: Lessons from a Multi-centre Collaborative Effort Across India

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Imaging in Neuro-Melioidosis: Lessons from a Multi-centre Collaborative Effort Across India

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading